I normally tune the Helli engines by the sound they make and then back off 1/4 turn on the rich side just to be safe (don't like the rotas to stop suddenly
)
But most of mine are ASP and the carbs are pretty much self adjusting and all I have to worry about is one mixture screw
I did tune a couple of bigger (strimmer size ) motors a while back and the methoud I used was to adjust the low mix screw to as lean as it would go and still pick up then wind it out until it would pick up fast without too much smoke or hunting
Then wind the hig mix in until it starts to mis on full throttle and slowly wind it out until I could get full power an a little bit of smoke then keep an eye on the temprature (don't let it overheat)
As you are gonna have to run it without load while you tune it it migh be worth setting it a bit rich as it will need more when its under load
One last bit of advice have you tried searching the net as I have found lots tuning advice online
Jason